Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model

Insertional leukemogenesis represents the major risk factor of hematopoietic stem cell (HSC) based gene therapy utilizing integrating viral vectors. To develop a pre-clinical model for the evaluation of vector-related genotoxicity directly in the relevant human target cells, cord blood CD34(+) HSCs...

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Main Authors: Haemmerle, Reinhard, Phaltane, Ruhi, Rothe, Michael, Schröder, Simon, Schambach, Axel, Moritz, Thomas, Modlich, Ute
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217076/
https://ncbi.nlm.nih.gov/pubmed/25291142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.51
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