Structure–Activity Relationship Studies of Indole-Based Compounds as Small Molecule HIV-1 Fusion Inhibitors Targeting Glycoprotein 41

[Image: see text] We previously described indole-containing compounds with the potential to inhibit HIV-1 fusion by targeting the hydrophobic pocket of transmembrane glycoprotein gp41. Here we report optimization and structure–activity relationship studies on the basic scaffold, defining the role of...

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Main Authors: Zhou, Guangyan, Sofiyev, Vladimir, Kaur, Hardeep, Snyder, Beth A., Mankowski, Marie K., Hogan, Priscilla A., Ptak, Roger G., Gochin, Miriam
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216203/
https://ncbi.nlm.nih.gov/pubmed/24856833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500344y
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