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Enhanced potency of bivalent small molecule gp41 inhibitors
Low molecular weight peptidomimetic inhibitors with hydrophobic pocket binding properties and moderate fusion inhibitory activity against HIV-1 gp41-mediated cell fusion were elaborated by increasing the available surface area for interacting with the heptad repeat-1 (HR1) coiled coil on gp41. Two t...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5260928/ https://ncbi.nlm.nih.gov/pubmed/27908751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.11.010 |
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