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Tumor Suppressors TSC1 and TSC2 Differentially Modulate Actin Cytoskeleton and Motility of Mouse Embryonic Fibroblasts

TSC1 and TSC2 mutations cause neoplasms in rare disease pulmonary LAM and neuronal pathfinding in hamartoma syndrome TSC. The specific roles of TSC1 and TSC2 in actin remodeling and the modulation of cell motility, however, are not well understood. Previously, we demonstrated that TSC1 and TSC2 regu...

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Bibliografische gegevens
Hoofdauteurs: Goncharova, Elena A., James, Melane L., Kudryashova, Tatiana V., Goncharov, Dmitry A., Krymskaya, Vera P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216017/
https://ncbi.nlm.nih.gov/pubmed/25360538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111476
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