TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase

Tuberous sclerosis complex (TSC) 1 and TSC2 are thought to be involved in protein translational regulation and cell growth, and loss of their function is a cause of TSC and lymphangioleiomyomatosis (LAM). However, TSC1 also activates Rho and regulates cell adhesion. We found that TSC2 modulates acti...

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Bibliographic Details
Main Authors: Goncharova, Elena, Goncharov, Dmitry, Noonan, Daniel, Krymskaya, Vera P.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2004
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172598/
https://ncbi.nlm.nih.gov/pubmed/15611338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200405130
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