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Tumor Suppressors TSC1 and TSC2 Differentially Modulate Actin Cytoskeleton and Motility of Mouse Embryonic Fibroblasts

TSC1 and TSC2 mutations cause neoplasms in rare disease pulmonary LAM and neuronal pathfinding in hamartoma syndrome TSC. The specific roles of TSC1 and TSC2 in actin remodeling and the modulation of cell motility, however, are not well understood. Previously, we demonstrated that TSC1 and TSC2 regu...

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書誌詳細
主要な著者: Goncharova, Elena A., James, Melane L., Kudryashova, Tatiana V., Goncharov, Dmitry A., Krymskaya, Vera P.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216017/
https://ncbi.nlm.nih.gov/pubmed/25360538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111476
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