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Allosteric Response and Substrate Sensitivity in Peptide Binding of the Signal Recognition Particle
We characterize the conformational dynamics and substrate selectivity of the signal recognition particle (SRP) using a thermodynamic free energy cycle approach and microsecond timescale molecular dynamics simulations. The SRP is a central component of the co-translational protein targeting machinery...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4215262/ https://ncbi.nlm.nih.gov/pubmed/25237192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.584912 |
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