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Allosteric Response and Substrate Sensitivity in Peptide Binding of the Signal Recognition Particle

We characterize the conformational dynamics and substrate selectivity of the signal recognition particle (SRP) using a thermodynamic free energy cycle approach and microsecond timescale molecular dynamics simulations. The SRP is a central component of the co-translational protein targeting machinery...

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Detalhes bibliográficos
Main Authors: Wang, Connie Y., Miller, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215262/
https://ncbi.nlm.nih.gov/pubmed/25237192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.584912
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