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Allosteric Response and Substrate Sensitivity in Peptide Binding of the Signal Recognition Particle

We characterize the conformational dynamics and substrate selectivity of the signal recognition particle (SRP) using a thermodynamic free energy cycle approach and microsecond timescale molecular dynamics simulations. The SRP is a central component of the co-translational protein targeting machinery...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wang, Connie Y., Miller, Thomas F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215262/
https://ncbi.nlm.nih.gov/pubmed/25237192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.584912
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