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Allosteric Response and Substrate Sensitivity in Peptide Binding of the Signal Recognition Particle

We characterize the conformational dynamics and substrate selectivity of the signal recognition particle (SRP) using a thermodynamic free energy cycle approach and microsecond timescale molecular dynamics simulations. The SRP is a central component of the co-translational protein targeting machinery...

詳細記述

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書誌詳細
主要な著者: Wang, Connie Y., Miller, Thomas F.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215262/
https://ncbi.nlm.nih.gov/pubmed/25237192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.584912
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