Pediatric Microdose Study of [(14)C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept

BACKGROUND: Pediatric drug development is hampered by practical, ethical, and scientific challenges. Microdosing is a promising new method to obtain pharmacokinetic data in children with minimal burden and minimal risk. The use of a labeled oral microdose offers the added benefit to study intestinal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mooij, Miriam G., van Duijn, Esther, Knibbe, Catherijne A. J., Windhorst, Albert D., Hendrikse, N. Harry, Vaes, Wouter H. J., Spaans, Edwin, Fabriek, Babs O., Sandman, Hugo, Grossouw, Dimitri, Hanff, Lidwien M., Janssen, Paul J. J. M., Koch, Birgit C. P., Tibboel, Dick, de Wildt, Saskia N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer International Publishing 2014
Gaiak:
Short Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213380/
https://ncbi.nlm.nih.gov/pubmed/25227283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-014-0176-8
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