Model-Based Exposure–Response Analysis of Apixaban to Quantify Bleeding Risk in Special Populations of Subjects Undergoing Orthopedic Surgery

Population pharmacokinetic (PK) and exposure–response analyses of apixaban were performed using data from phase I–III studies to predict bleeding risks for patients receiving apixaban 2.5 mg b.i.d. after total knee or hip replacement (TKR, THR) surgery (N = 5,510). Renal function, age, gender, and b...

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Detaylı Bibliyografya
Asıl Yazarlar: Leil, T A, Frost, C, Wang, X, Pfister, M, LaCreta, F
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2014
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211262/
https://ncbi.nlm.nih.gov/pubmed/25229619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2014.34
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