Model-Based Exposure–Response Analysis of Apixaban to Quantify Bleeding Risk in Special Populations of Subjects Undergoing Orthopedic Surgery

Population pharmacokinetic (PK) and exposure–response analyses of apixaban were performed using data from phase I–III studies to predict bleeding risks for patients receiving apixaban 2.5 mg b.i.d. after total knee or hip replacement (TKR, THR) surgery (N = 5,510). Renal function, age, gender, and b...

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Hlavní autoři: Leil, T A, Frost, C, Wang, X, Pfister, M, LaCreta, F
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211262/
https://ncbi.nlm.nih.gov/pubmed/25229619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2014.34
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