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Cellular manganese content is developmentally regulated in human dopaminergic neurons

Manganese (Mn) is both an essential biological cofactor and neurotoxicant. Disruption of Mn biology in the basal ganglia has been implicated in the pathogenesis of neurodegenerative disorders, such as parkinsonism and Huntington's disease. Handling of other essential metals (e.g. iron and zinc)...

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Autores principales: Kumar, Kevin K., Lowe, Jr., Edward W., Aboud, Asad A., Neely, M. Diana, Redha, Rey, Bauer, Joshua A., Odak, Mihir, Weaver, C. David, Meiler, Jens, Aschner, Michael, Bowman, Aaron B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210885/
https://ncbi.nlm.nih.gov/pubmed/25348053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06801
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