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Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson’s disease

Parkinson’s Disease (PD) is the second most common neurodegenerative disease, yet its etiology and pathogenesis are poorly understood. PD is characterized by selective dopaminergic (DAergic) degeneration and progressive hypokinetic motor impairment. Mutations in dj-1 cause autosomal recessive early-...

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Dettagli Bibliografici
Pubblicato in:Metallomics
Autori principali: Chen, Pan, DeWitt, Margaret R., Bornhost, Julia, Soares, Felix A., Mukhopadhyay, Somshuvra, Bowman, Aaron B., Aschner, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479152/
https://ncbi.nlm.nih.gov/pubmed/25531510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4mt00292j
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