Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson’s disease

Parkinson’s Disease (PD) is the second most common neurodegenerative disease, yet its etiology and pathogenesis are poorly understood. PD is characterized by selective dopaminergic (DAergic) degeneration and progressive hypokinetic motor impairment. Mutations in dj-1 cause autosomal recessive early-...

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Bibliographic Details
Published in:Metallomics
Main Authors: Chen, Pan, DeWitt, Margaret R., Bornhost, Julia, Soares, Felix A., Mukhopadhyay, Somshuvra, Bowman, Aaron B., Aschner, Michael
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479152/
https://ncbi.nlm.nih.gov/pubmed/25531510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4mt00292j
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