Cellular manganese content is developmentally regulated in human dopaminergic neurons

Manganese (Mn) is both an essential biological cofactor and neurotoxicant. Disruption of Mn biology in the basal ganglia has been implicated in the pathogenesis of neurodegenerative disorders, such as parkinsonism and Huntington's disease. Handling of other essential metals (e.g. iron and zinc)...

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Main Authors: Kumar, Kevin K., Lowe, Jr., Edward W., Aboud, Asad A., Neely, M. Diana, Redha, Rey, Bauer, Joshua A., Odak, Mihir, Weaver, C. David, Meiler, Jens, Aschner, Michael, Bowman, Aaron B.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210885/
https://ncbi.nlm.nih.gov/pubmed/25348053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06801
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