JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response

Cancers result from the accumulation of genetic lesions, but the cellular consequences of driver mutations remain unclear, especially during the earliest stages of malignancy. The V617F mutation in the JAK2 non-receptor tyrosine kinase (JAK2V617F) is present as an early somatic event in most patient...

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Detalhes bibliográficos
Main Authors: Chen, Edwin, Ahn, Jong Sook, Massie, Charlie E., Clynes, David, Godfrey, Anna L., Li, Juan, Park, Hyun Jung, Nangalia, Jyoti, Silber, Yvonne, Mullally, Ann, Gibbons, Richard J., Green, Anthony R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210350/
https://ncbi.nlm.nih.gov/pubmed/25288776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401873111
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