The signaling phospholipid PIP(3) creates a new interaction surface on the nuclear receptor SF-1

The signaling phosphatidylinositol lipids PI(4,5)P(2) (PIP(2)) and PI(3,4,5)P(3) (PIP(3)) bind nuclear receptor 5A family (NR5As), but their regulatory mechanisms remain unknown. Here, the crystal structures of human NR5A1 (steroidogenic factor-1, SF-1) ligand binding domain (LBD) bound to PIP(2) an...

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Detalhes bibliográficos
Main Authors: Blind, Raymond D., Sablin, Elena P., Kuchenbecker, Kristopher M., Chiu, Hsiu-Ju, Deacon, Ashley M., Das, Debanu, Fletterick, Robert J., Ingraham, Holly A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210282/
https://ncbi.nlm.nih.gov/pubmed/25288771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416740111
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