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The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1
The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a ne...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587556/ https://ncbi.nlm.nih.gov/pubmed/19015525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808936105 |
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