The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a ne...

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Detaylı Bibliyografya
Asıl Yazarlar: Sablin, Elena P., Woods, April, Krylova, Irina N., Hwang, Peter, Ingraham, Holly A., Fletterick, Robert J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587556/
https://ncbi.nlm.nih.gov/pubmed/19015525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808936105
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