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Structural and Functional Characterization of Cleavage and Inactivation of Human Serine Protease Inhibitors by the Bacterial SPATE Protease EspPα from Enterohemorrhagic E. coli

EspPα and EspI are serine protease autotransporters found in enterohemorrhagic Escherichia coli. They both belong to the SPATE autotransporter family and are believed to contribute to pathogenicity via proteolytic cleavage and inactivation of different key host proteins during infection. Here, we de...

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Bibliografiske detaljer
Main Authors: Weiss, André, Joerss, Hanna, Brockmeyer, Jens
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210187/
https://ncbi.nlm.nih.gov/pubmed/25347319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111363
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