EspP, a Serine Protease of Enterohemorrhagic Escherichia coli, Impairs Complement Activation by Cleaving Complement Factors C3/C3b and C5

Hemolytic-uremic syndrome (HUS) is a life-threatening disorder characterized by hemolytic anemia, thrombocytopenia, and renal insufficiency. It is caused mainly by infections with enterohemorrhagic Escherichia coli (EHEC). Recently, Shiga toxin 2, the best-studied virulence factor of EHEC, was repor...

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Autori principali: Orth, Dorothea, Ehrlenbach, Silvia, Brockmeyer, Jens, Khan, Abdul Basit, Huber, Georg, Karch, Helge, Sarg, Bettina, Lindner, Herbert, Würzner, Reinhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950363/
https://ncbi.nlm.nih.gov/pubmed/20643852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00488-10
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