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Structural and Functional Characterization of Cleavage and Inactivation of Human Serine Protease Inhibitors by the Bacterial SPATE Protease EspPα from Enterohemorrhagic E. coli

EspPα and EspI are serine protease autotransporters found in enterohemorrhagic Escherichia coli. They both belong to the SPATE autotransporter family and are believed to contribute to pathogenicity via proteolytic cleavage and inactivation of different key host proteins during infection. Here, we de...

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Autors principals: Weiss, André, Joerss, Hanna, Brockmeyer, Jens
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210187/
https://ncbi.nlm.nih.gov/pubmed/25347319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111363
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