RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response

The post-translational modification of DNA repair and checkpoint proteins by ubiquitin and small ubiquitin-like modifier (SUMO) critically orchestrates the DNA damage response (DDR). The ubiquitin ligase RNF4 integrates signaling by SUMO and ubiquitin, through its selective recognition and ubiquitin...

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Detalles Bibliográficos
Autores principales: Groocock, Lynda M, Nie, Minghua, Prudden, John, Moiani, Davide, Wang, Tao, Cheltsov, Anton, Rambo, Robert P, Arvai, Andrew S, Hitomi, Chiharu, Tainer, John A, Luger, Karolin, Perry, J Jefferson P, Lazzerini-Denchi, Eros, Boddy, Michael N
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Scientific Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210088/
https://ncbi.nlm.nih.gov/pubmed/24714598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338369
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