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SUMO-Targeted Ubiquitin Ligase, Rad60, and Nse2 SUMO Ligase Suppress Spontaneous Top1–Mediated DNA Damage and Genome Instability

Through as yet undefined proteins and pathways, the SUMO-targeted ubiquitin ligase (STUbL) suppresses genomic instability by ubiquitinating SUMO conjugated proteins and driving their proteasomal destruction. Here, we identify a critical function for fission yeast STUbL in suppressing spontaneous and...

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Bibliografiske detaljer
Main Authors: Heideker, Johanna, Prudden, John, Perry, J. Jefferson P., Tainer, John A., Boddy, Michael N.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048374/
https://ncbi.nlm.nih.gov/pubmed/21408210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001320
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