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The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C
The cardiac isoform of troponin I (cTnI) has a unique 31-residue N-terminal region that binds cardiac troponin C (cTnC) to increase the calcium sensitivity of the sarcomere. The interaction can be abolished by cTnI phosphorylation at Ser22 and Ser23, an important mechanism for regulating cardiac con...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210035/ https://ncbi.nlm.nih.gov/pubmed/25246568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410775111 |
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