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Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch Region of Cardiac Troponin I and W7: The Basis of W7 as an Inhibitor of Cardiac Muscle Contraction

The solution structure of Ca(2+)-bound regulatory domain of cardiac troponin C (cNTnC) in complex with the switch region of troponin I (cTnI(147-163)) and the calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfinamide (W7), has been determined by NMR spectroscopy. The structure reveal...

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Autors principals: Oleszczuk, Marta, Robertson, Ian M., Li, Monica X., Sykes, Brian D.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854253/
https://ncbi.nlm.nih.gov/pubmed/20116385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.01.016
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