The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C

The cardiac isoform of troponin I (cTnI) has a unique 31-residue N-terminal region that binds cardiac troponin C (cTnC) to increase the calcium sensitivity of the sarcomere. The interaction can be abolished by cTnI phosphorylation at Ser22 and Ser23, an important mechanism for regulating cardiac con...

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Bibliographic Details
Main Authors: Hwang, Peter M., Cai, Fangze, Pineda-Sanabria, Sandra E., Corson, David C., Sykes, Brian D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210035/
https://ncbi.nlm.nih.gov/pubmed/25246568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410775111
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