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Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance

Alternating antibiotic therapy, in which pairs of drugs are cycled during treatment, has been suggested as a means to inhibit the evolution of de novo resistance while avoiding the toxicity associated with more traditional combination therapy. However, it remains unclear under which conditions and b...

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Bibliografiske detaljer
Main Authors: Kim, Seungsoo, Lieberman, Tami D., Kishony, Roy
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210010/
https://ncbi.nlm.nih.gov/pubmed/25246554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409800111
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