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Evolutionary paths to antibiotic resistance under dynamically sustained drug stress
Antibiotic resistance can evolve through sequential accumulation of multiple mutations(1). To study such gradual evolution, we developed a selection device, the morbidostat, which continuously monitors bacterial growth and dynamically regulates drug concentrations such that the evolving population i...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3534735/ https://ncbi.nlm.nih.gov/pubmed/22179135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.1034 |
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