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Evolutionary paths to antibiotic resistance under dynamically sustained drug stress

Antibiotic resistance can evolve through sequential accumulation of multiple mutations(1). To study such gradual evolution, we developed a selection device, the morbidostat, which continuously monitors bacterial growth and dynamically regulates drug concentrations such that the evolving population i...

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Main Authors: Toprak, Erdal, Veres, Adrian, Michel, Jean-Baptiste, Chait, Remy, Hartl, Daniel L., Kishony, Roy
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534735/
https://ncbi.nlm.nih.gov/pubmed/22179135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.1034
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