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Non-optimal microbial response to antibiotics underlies suppressive drug interactions
Antibiotics inhibiting translation can increase bacterial growth rate in the presence of DNA synthesis inhibitors. Here, we show that this extreme type of drug antagonism, termed suppression, results from non-optimal regulation of ribosomal genes, leading to sub-maximal growth in the presence of DNA...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838386/ https://ncbi.nlm.nih.gov/pubmed/19914165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.10.025 |
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