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Non-optimal microbial response to antibiotics underlies suppressive drug interactions

Antibiotics inhibiting translation can increase bacterial growth rate in the presence of DNA synthesis inhibitors. Here, we show that this extreme type of drug antagonism, termed suppression, results from non-optimal regulation of ribosomal genes, leading to sub-maximal growth in the presence of DNA...

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Detalhes bibliográficos
Main Authors: Bollenbach, Tobias, Quan, Selwyn, Chait, Remy, Kishony, Roy
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838386/
https://ncbi.nlm.nih.gov/pubmed/19914165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.10.025
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