Proline Editing: A General and Practical Approach to the Synthesis of Functionally and Structurally Diverse Peptides. Analysis of Steric versus Stereoelectronic Effects of 4-Substituted Prolines on Conformation within Peptides

Functionalized proline residues have diverse applications. Herein we describe a practical approach, proline editing, for the synthesis of peptides with stereospecifically modified proline residues. Peptides are synthesized by standard solid-phase-peptide-synthesis to incorporate Fmoc-Hydroxyproline...

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Hlavní autoři: Pandey, Anil K., Naduthambi, Devan, Thomas, Krista M., Zondlo, Neal J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209921/
https://ncbi.nlm.nih.gov/pubmed/23402492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3109664
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