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Electronic and steric control of n→π* interactions: stabilization of the α-helix conformation without a hydrogen bond

The preferred conformations of peptides and proteins are dependent on local interactions that bias the conformational ensemble. The n→π* interaction between consecutive carbonyls promotes compact conformations, including α-helix and polyproline II helix. In order to further understand the n→π* inter...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Wenzell, Nicole A., Ganguly, Himal K., Pandey, Anil K., Bhatt, Megh R., Yap, Glenn P. A., Zondlo, Neal J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458595/
https://ncbi.nlm.nih.gov/pubmed/30548564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800785
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