Heterodimeric Bispecific Single-Chain Variable-Fragment Antibodies Against EpCAM and CD16 Induce Effective Antibody-Dependent Cellular Cytotoxicity Against Human Carcinoma Cells

A heterodimeric bispecific biological recombinant drug was synthesized by splicing DNA fragments from two fully humanized single-chain variable-fragment (scFV) antibody fragments forming a novel drug simultaneously recognizing the CD16 natural killer (NK) cell marker and the cancer marker epithelial...

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Bibliographic Details
Main Authors: Vallera, Daniel A., Zhang, Bin, Gleason, Michelle K., Oh, Seunguk, Weiner, Louis M., Kaufman, Dan S., McCullar, Valarie, Miller, Jeffrey S., Verneris, Michael R.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2013
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209492/
https://ncbi.nlm.nih.gov/pubmed/23611188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cbr.2012.1329
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