Human 2-Oxoglutarate Dehydrogenase Complex E1 Component Forms a Thiamin-derived Radical by Aerobic Oxidation of the Enamine Intermediate

Herein are reported unique properties of the human 2-oxoglutarate dehydrogenase multienzyme complex (OGDHc), a rate-limiting enzyme in the Krebs (citric acid) cycle. (a) Functionally competent 2-oxoglutarate dehydrogenase (E1o-h) and dihydrolipoyl succinyltransferase components have been expressed a...

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Bibliographic Details
Main Authors: Nemeria, Natalia S., Ambrus, Attila, Patel, Hetalben, Gerfen, Gary, Adam-Vizi, Vera, Tretter, Laszlo, Zhou, Jieyu, Wang, Junjie, Jordan, Frank
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207997/
https://ncbi.nlm.nih.gov/pubmed/25210035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591073
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