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Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress

Alpha-ketoglutarate dehydrogenase (α-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the Krebs cycle. It catalyses the conversion of α-ketoglutarate to succinyl-CoA and produces NADH directly providing electrons for the respiratory chain. α-KGDH is sensitive to r...

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Autores principales: Tretter, Laszlo, Adam-Vizi, Vera
Formato: Artigo
Lenguaje:Inglês
Publicado: The Royal Society 2005
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569585/
https://ncbi.nlm.nih.gov/pubmed/16321804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2005.1764
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