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Inhibition of Krebs Cycle Enzymes by Hydrogen Peroxide: A Key Role of α-Ketoglutarate Dehydrogenase in Limiting NADH Production under Oxidative Stress

In this study we addressed the function of the Krebs cycle to determine which enzyme(s) limits the availability of reduced nicotinamide adenine dinucleotide (NADH) for the respiratory chain under H(2)O(2)-induced oxidative stress, in intact isolated nerve terminals. The enzyme that was most vulnerab...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Tretter, Laszlo, Adam-Vizi, Vera
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773008/
https://ncbi.nlm.nih.gov/pubmed/11124972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-24-08972.2000
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