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Generation of Reactive Oxygen Species in the Reaction Catalyzed by α-Ketoglutarate Dehydrogenase

α-Ketoglutarate dehydrogenase (α-KGDH), a key enzyme in the Krebs' cycle, is a crucial early target of oxidative stress (Tretter and Adam-Vizi, 2000). The present study demonstrates that α-KGDH is able to generate H(2)O(2) and, thus, could also be a source of reactive oxygen species (ROS) in mi...

詳細記述

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書誌詳細
出版年:J Neurosci
主要な著者: Tretter, Laszlo, Adam-Vizi, Vera
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729921/
https://ncbi.nlm.nih.gov/pubmed/15356188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1842-04.2004
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