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Generation of Reactive Oxygen Species in the Reaction Catalyzed by α-Ketoglutarate Dehydrogenase
α-Ketoglutarate dehydrogenase (α-KGDH), a key enzyme in the Krebs' cycle, is a crucial early target of oxidative stress (Tretter and Adam-Vizi, 2000). The present study demonstrates that α-KGDH is able to generate H(2)O(2) and, thus, could also be a source of reactive oxygen species (ROS) in mi...
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| Publicado en: | J Neurosci |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Society for Neuroscience
2004
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6729921/ https://ncbi.nlm.nih.gov/pubmed/15356188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1842-04.2004 |
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