A multipronged approach unravels unprecedented protein–protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex

The human 2-oxoglutaric acid dehydrogenase complex (hOGDHc) plays a pivotal role in the tricarboxylic acid (TCA) cycle, and its diminished activity is associated with neurodegenerative diseases. The hOGDHc comprises three components, hE1o, hE2o, and hE3, and we recently reported functionally active...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhou, Jieyu, Yang, Luying, Ozohanics, Oliver, Zhang, Xu, Wang, Junjie, Ambrus, Attila, Arjunan, Palaniappa, Brukh, Roman, Nemeria, Natalia S., Furey, William, Jordan, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302161/
https://ncbi.nlm.nih.gov/pubmed/30323066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005432
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