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A multipronged approach unravels unprecedented protein–protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex

The human 2-oxoglutaric acid dehydrogenase complex (hOGDHc) plays a pivotal role in the tricarboxylic acid (TCA) cycle, and its diminished activity is associated with neurodegenerative diseases. The hOGDHc comprises three components, hE1o, hE2o, and hE3, and we recently reported functionally active...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhou, Jieyu, Yang, Luying, Ozohanics, Oliver, Zhang, Xu, Wang, Junjie, Ambrus, Attila, Arjunan, Palaniappa, Brukh, Roman, Nemeria, Natalia S., Furey, William, Jordan, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302161/
https://ncbi.nlm.nih.gov/pubmed/30323066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005432
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