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Multiple roles of mobile active center loops in the E1 component of the Escherichia coli pyruvate dehydrogenase complex - Linkage of protein dynamics to catalysis

The region encompassing residues 401–413 on the E1 component of the pyruvate dehydrogenase multienzyme complex from Escherichia coli comprises a loop (the inner loop) which was not seen in the X-ray structure in the presence of thiamin diphosphate, the required cofactor for the enzyme. This loop is...

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Detalhes bibliográficos
Main Authors: Jordan, Frank, Arjunan, Palaniappa, Kale, Sachin, Nemeria, Natalia S., Furey, William
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759092/
https://ncbi.nlm.nih.gov/pubmed/20160956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcatb.2009.04.008
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