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Efficient coupling of catalysis and dynamics in the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex

Protein motions are ubiquitous and are intrinsically coupled to catalysis. Their specific roles, however, remain largely elusive. Dynamic loops at the active center of the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex are essential for several catalytic functions starti...

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Bibliografiske detaljer
Main Authors: Kale, Sachin, Ulas, Gözde, Song, Jaeyoung, Brudvig, Gary W., Furey, William, Jordan, Frank
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234108/
https://ncbi.nlm.nih.gov/pubmed/18216265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709328105
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