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Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis
Mcl-1 is a unique antiapoptotic Bcl2 family member with a short half-life due to its rapid turnover through ubiquitination. We discovered that Ku70, a DNA double-strand break repair protein, functions as a deubiquitinase to stabilize Mcl-1. Ku70 knockout in mouse embryonic fibroblast (MEF) cells or...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4207484/ https://ncbi.nlm.nih.gov/pubmed/24769731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.42 |
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