Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis

Mcl-1 is a unique antiapoptotic Bcl2 family member with a short half-life due to its rapid turnover through ubiquitination. We discovered that Ku70, a DNA double-strand break repair protein, functions as a deubiquitinase to stabilize Mcl-1. Ku70 knockout in mouse embryonic fibroblast (MEF) cells or...

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Detalhes bibliográficos
Main Authors: Wang, B, Xie, M, Li, R, Owonikoko, T K, Ramalingam, S S, Khuri, F R, Curran, W J, Wang, Y, Deng, X
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207484/
https://ncbi.nlm.nih.gov/pubmed/24769731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.42
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