Enzymatic and Cryoreduction EPR Studies of the Hydroxylation of Methylated N(ω)-Hydroxy-l-arginine Analogues by Nitric Oxide Synthase from Geobacillus stearothermophilus

[Image: see text] Nitric oxide synthase (NOS) catalyzes the conversion of l-arginine to l-citrulline and NO in a two-step process involving the intermediate N(ω)-hydroxy-l-arginine (NHA). It was shown that Cpd I is the oxygenating species for l-arginine; the hydroperoxo ferric intermediate is the re...

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Egile Nagusiak: Davydov, Roman, Labby, Kristin Jansen, Chobot, Sarah E., Lukoyanov, Dmitriy A., Crane, Brian R., Silverman, Richard B., Hoffman, Brian M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2014
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204881/
https://ncbi.nlm.nih.gov/pubmed/25251261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500485z
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