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Mismatch repair-dependent G(2) checkpoint induced by low doses of S(N)1 type methylating agents requires the ATR kinase
S(N)1-type alkylating agents represent an important class of chemotherapeutics, but the molecular mechanisms underlying their cytotoxicity are unknown. Thus, although these substances modify predominantly purine nitrogen atoms, their toxicity appears to result from the processing of O(6)-methylguani...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC420358/ https://ncbi.nlm.nih.gov/pubmed/15175264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.294404 |
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