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Interplay of DNA Repair Pathways Controls Methylation Damage Toxicity in Saccharomyces cerevisiae
Methylating agents of S(N)1 type are widely used in cancer chemotherapy, but their mode of action is poorly understood. In particular, it is unclear how the primary cytotoxic lesion, O(6)-methylguanine ((Me)G), causes cell death. One hypothesis stipulates that binding of mismatch repair (MMR) protei...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Genetics Society of America
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516062/ https://ncbi.nlm.nih.gov/pubmed/18579505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.089979 |
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