Mismatch repair-dependent G(2) checkpoint induced by low doses of S(N)1 type methylating agents requires the ATR kinase

S(N)1-type alkylating agents represent an important class of chemotherapeutics, but the molecular mechanisms underlying their cytotoxicity are unknown. Thus, although these substances modify predominantly purine nitrogen atoms, their toxicity appears to result from the processing of O(6)-methylguani...

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Main Authors: Stojic, Lovorka, Mojas, Nina, Cejka, Petr, di Pietro, Massimiliano, Ferrari, Stefano, Marra, Giancarlo, Jiricny, Josef
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC420358/
https://ncbi.nlm.nih.gov/pubmed/15175264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.294404
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