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Glucocerebrosidase deficits in sporadic Parkinson disease
Parkinson disease (PD) is a progressive neurodegenerative movement disorder characterized pathologically by abnormal SNCA/α-synuclein protein inclusions in neurons. Impaired lysosomal autophagic degradation of cellular proteins is implicated in PD pathogenesis and progression. Heterozygous GBA mutat...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4203563/ https://ncbi.nlm.nih.gov/pubmed/24915553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.29074 |
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