Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice.

We have generated mice with a null mutation at the Ada locus, which encodes the purine catabolic enzyme adenosine deaminase (ADA, EC 3.5.4.4). ADA-deficient fetuses exhibited hepatocellular impairment and died perinatally. Their lymphoid tissues were not largely affected. Accumulation of ADA substra...

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Main Authors: Wakamiya, M, Blackburn, M R, Jurecic, R, McArthur, M J, Geske, R S, Cartwright, J, Mitani, K, Vaishnav, S, Belmont, J W, Kellems, R E
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC42023/
https://ncbi.nlm.nih.gov/pubmed/7731963
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