Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice.
We have generated mice with a null mutation at the Ada locus, which encodes the purine catabolic enzyme adenosine deaminase (ADA, EC 3.5.4.4). ADA-deficient fetuses exhibited hepatocellular impairment and died perinatally. Their lymphoid tissues were not largely affected. Accumulation of ADA substra...
محفوظ في:
| الحاوية / القاعدة: | Proc Natl Acad Sci U S A |
|---|---|
| المؤلفون الرئيسيون: | , , , , , , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
National Academy of Sciences
1995
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42023/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731963/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3673 |
| الوسوم: |
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