Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice.

We have generated mice with a null mutation at the Ada locus, which encodes the purine catabolic enzyme adenosine deaminase (ADA, EC 3.5.4.4). ADA-deficient fetuses exhibited hepatocellular impairment and died perinatally. Their lymphoid tissues were not largely affected. Accumulation of ADA substra...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Wakamiya, M, Blackburn, M R, Jurecic, R, McArthur, M J, Geske, R S, Cartwright, J, Mitani, K, Vaishnav, S, Belmont, J W, Kellems, R E
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1995
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42023/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731963/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3673
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